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This medication may be prescribed for the treatment of different health problems, like skin conditions, allergic disorders, arthritis, lupus, psoriasis, ulcerative colitis, or breathing disorders. When taking oral corticosteroids longer term, you may experience:. Who Shouldn’t Take Prednisone? Prednisone is a corticosteroid medicine used to decrease inflammation and keep your immune system in check, if it is overactive. Prednisone is used to treat allergic disorders, skin conditions, ulcerative colitis, Crohn’s disease, arthritis, lupus, psoriasis, asthma, chronic obstructive pulmonary disease (COPD) and many more conditions. This usually starts at prednisone 40 mg. Fluid retention, causing swelling in your lower legs. The chemical name for prednisone is pregna-1,4-diene-3,11,20-trione monohydrate,17,21-dihydroxy-. Deltasone might damage an unborn kid as it is FDA maternity group C. Prednisone, USP is a white to partially white, crystalline powder. 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