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Trazodone increases natural neurotransmitters in the central nervous system, essentially restoring depleted chemicals in the brain. However, it is very good at helping people sleep Trazodone is an FDA-approved drug for the treatment of a major depressive disorder. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. It’s best to give Trazodone before the trigger happens so that your dog is already calm when it begins to work Trazodone is nearly completely metabolized hepatically by hydroxylation and oxidation to metabolites that are probably inactive. I slowed down to 100, 50 then 25 for a week each. I've been on here all day looking at what people have to say about this medicine, and have been fairly. 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