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The active ingredient in Crestor is rosuvastatin. Reviewed by Mike Bohl, MD, MPH, ALM Written by Chimene Richa, MD table of contents Crestor vs. What Are Possible Side Effects of Lipitor? 7 out of 10 from a total of 101 ratings on Drugs. The trick is to weigh the potential for serious side effects against the gain you can get from the medication. Looking for Our Event, or Other Photography? Some simple steps can help minimize or avoid muscle problems from Crestor and other cholesterol-lowering drugs. 7 / 5 average rating with 751 reviews forCrestor Lowers cholesterol. 4k views Answered >2 years ago Thank 3 thanks View 1 more answer Last updated Jun 24, 2014. Crestor (rosuvastatin): Crestor is more potent , has more effect lowering the LDL (bad component), raising the HDL (the good component) than Lipitor, ( atorvastatin) and has fewer side effects. 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